Uncategorized

ESTUDIO GENÉTICO EN EL DÉFICIT DE DAO/HISTAMINOSIS

Publicado en por admin

ESTUDIO GENÉTICO EN EL DÉFICIT DE DAO/HISTAMINOSIS

QUE SE REALIZA EN ARGENTINA

 

Es evidente que uno de los factores por los que se produce déficit de DAO es la genética. En un mismo grupo familiar, sus miembros comparten el déficit y muchas patologías crónicas tildadas hasta ahora como “hereditarias”.

La secuencia genética de la DAO se encuentra en un fragmento localizado en el cromosoma 7 (7q34-q36) del genoma humano y está compuesto por 5 exones y 4 intrones.

Se han encontrado muchas diferencias entre la secuencia de exones e intrones de este gen que son debidas a su polimorfismo genético. En total, según datos del Centro Nacional de Información Biotecnológica (NCBI), existen 85 variantes de un solo núcleotido (SNP) localizados e identificados en el gen humano de la DAO (AOC1). 17 de estos SNPs se encuentran en los exones, de los cuales 7 producen sustitución de los aminoácidos, siendo candidatos para causar alteraciones en la capacidad metabólica de la enzima.

De todos los polimorfismos encontrados en la secuencia del gen AOC1, 3 de estos polimorfismos (con referencia: rs1015611, rs1049742 y rs1049793) producen baja actividad enzimática en la metabolización de la histamina.

 

 

Personas portadoras de estos polimorfismos presentan una menor actividad de Diamino Oxidasa que individuos no portadores, siendo las diferencias en sus niveles de actividad significativas. Los estudios indican que este tipo de polimorfismos ocurren con una frecuencia global aproximada del 10-13%, afectando especialmente a mujeres de mediana edad.

Otros polimorfismos estudiados de sustitución de aminoácidos en el gen de DAO no muestran cambios en su actividad enzimática. Por otra parte, se ha asociado la variante p.T16M a un mayor riesgo de hipersensibilidad a AINES (fármacos antiinflamatorios no esteroideos), habiéndose propuesto como un biomarcador de respuesta clínica al tratamiento de patologías con estos fármacos.

 

 

Prof. Dr. Eduardo H. Raimondi

 

admin

782 comentarios sobre “ESTUDIO GENÉTICO EN EL DÉFICIT DE DAO/HISTAMINOSIS”

  5. Dakota dice:

    With havin so much content and articles do you ever run into any problems of plagorism or copyright violation?
    My blog has a lot of exclusive content I’ve either created myself or outsourced
    but it appears a lot of it is popping it up all over the internet without my
    permission. Do you know any ways to help prevent content from being stolen? I’d genuinely appreciate it.

  6. Virginia dice:

    Hola! Tengo la misma duda que Melanie, puede realizarse el estudio en Argentina? Donde y cual es el costo? Gracias!

  8. Refugia dice:

    Your style is unique compared to other people I have read stuff
    from. I appreciate you for posting when you’ve got the opportunity, Guess I will
    just book mark this page.

  11. Alfonzo dice:

    Your method of explaining everything in this piece of writing is genuinely fastidious, every one be capable of without difficulty be aware of
    it, Thanks a lot.

  17. web hosting or dice:

    I have been surfing online more than 3 hours today, yet I never
    found any interesting article like yours. It’s pretty worth
    enough for me. Personally, if all site owners and
    bloggers made good content as you did, the internet will be much more useful
    than ever before.

  18. http://j.mp/3sYk1u8 dice:

    I absolutely love your blog and find almost all of your post’s to be just what I’m looking for.
    Does one offer guest writers to write content in your case?

    I wouldn’t mind creating a post or elaborating on a lot of the
    subjects you write regarding here. Again, awesome site!

  19. http://bitly.com/ dice:

    I do trust all the ideas you have introduced in your post.
    They’re very convincing and will certainly work.
    Still, the posts are very quick for novices. Could you please
    lengthen them a little from next time? Thank you for
    the post.

  21. asmr that dice:

    Hello there, I do believe your web site might be having web browser compatibility issues.
    When I look at your site in Safari, it looks fine however, when opening
    in IE, it’s got some overlapping issues. I simply
    wanted to give you a quick heads up! Aside from that, excellent
    website!

  22. asmr and dice:

    Hey there, I think your website might be having browser compatibility
    issues. When I look at your blog site in Firefox, it looks fine but
    when opening in Internet Explorer, it has some overlapping.
    I just wanted to give you a quick heads up!
    Other then that, excellent blog!

  23. asmr and dice:

    Hey There. I discovered your weblog the use of msn. This is an extremely well written article.
    I’ll make sure to bookmark it and come back to read extra of your
    useful information. Thanks for the post. I will
    definitely comeback.

  24. what asmr dice:

    Please let me know if you’re looking for a writer for your blog.
    You have some really great posts and I think I would be a good asset.
    If you ever want to take some of the load off, I’d love to write some articles for your
    blog in exchange for a link back to mine. Please shoot me an e-mail if interested.
    Thank you!

  32. Website Vật nuôi dice:

    Magnificent beat ! I wish to apprentice while you amend your site, how can i subscribe for a weblog website? The account helped me a acceptable deal. I have been a little bit acquainted of this your broadcast provided brilliant clear concept

  50. over here dice:

    Does your site have a contact page? I’m having problems locating it but, I’d like to shoot you an email. I’ve got some recommendations for your blog you might be interested in hearing. Either way, great website and I look forward to seeing it improve over time.

  113. Психолог онлайн dice:

    Услуги аналитического психолога, психотерапевта.
    Психолог онлайн Психолог,Психолог онлайн.
    Психолог в Харькове, консультация.
    Рейтинг психологов. Помощь профессионального Психолога.

    Сімейні консультації. Услуги
    консультации психолога.

  149. Giống chó săn vịt dice:

    I?m impressed, I must say. Really rarely do I encounter a blog that?s both educative and entertaining, and let me tell you, you have hit the nail on the head. Your idea is outstanding; the issue is something that not enough people are speaking intelligently about. I am very happy that I stumbled across this in my search for something relating to this.

  191. lông ngắn anh dễ thương dice:

    I?m impressed, I must say. Really rarely do I encounter a blog that?s both educative and entertaining, and let me tell you, you have hit the nail on the head. Your idea is outstanding; the issue is something that not enough people are speaking intelligently about. I am very happy that I stumbled across this in my search for something relating to this.

  195. Giống mèo anh lông ngắn dice:

    When I originally commented I clicked the -Notify me when new comments are added- checkbox and now each time a comment is added I get four emails with the same comment. Is there any way you can remove me from that service? Thanks!

  212. Giá mèo anh lông ngắn dễ thương dice:

    The next time I read a blog, I hope that it doesnt disappoint me as much as this one. I mean, I know it was my choice to read, but I actually thought youd have something interesting to say. All I hear is a bunch of whining about something that you could fix if you werent too busy looking for attention.

  330. omzpih2019 dice:

    Расстановки по Хеллингеру. Метод расстановок. Новые семейные расстановки. Метод Берта Хеллингера. Системно-феноменологическая психотерапия. Системно-феноменологическая психотерапия. Системные-расстановки. Семейное консультирование и психотерапия. Духовные расстановки. Расстановки по Хеллингеру. Расстановки по Хеллингеру. Семейное консультирование и психотерапия. Глубинные системные расстановки. Системно-феноменологическая психотерапия. Растановки. Новые семейные расстановки. Метод Берта Хеллингера. Системно-семейные расстановки.

    Любовь должна быть включена в порядок. Порядок является предпосылкой любви. Это действует и в природе: дерево развивается согласно внутреннему порядку. Его нельзя изменить. Оно может развиваться только в рамках этого порядка. То же самое касается любви и межличностных отношений: они могут получить свое развитие только в рамках порядка. Этот порядок задан.
    Второй порядок состоит в том, что между партнерами должен быть баланс между «давать» и «брать». Если один вынужден давать больше, чем другой, это разрушает отношения. Партнерству необходим этот баланс.
    Одной из составляющих хороших взаимоотношений является баланс брать-давать. Это о том, что мы вкладываем примерно столько сил, времени, ресурсов, сколько получаем взамен. Когда мы получаем отклик от мира, от людей, у нас волшебным образом появляются силы и желание давать больше. Мы чувствуем себя нужными, счастливыми, в гармонии с собой и миром.

    Но иногда этот баланс может нарушаться. Человек начинает или слишком много давать, или слишком много брать.

    ——
    Организационные расстановки. Системно-семейные расстановки. Системные перестановки. Метод расстановок. Растановки. Семейное консультирование и психотерапия. Расстановки по Хеллингеру. Растановки. Расстановки. Системные расстановки. Bert Hellinger. Расстановки.
    ——
    Истощение накапливается незаметно, медленно, но оно неутомимо приводит к неким последствиям.

    Когда человек даёт больше, чем получает, то со временем в нём накапливается неудовлетворённость всем происходящим: “Я стараюсь, а меня не ценят”, “Я же всё делаю для всех, а чувствую себя таким несчастным”, “Они не благодарны”, “Я последнюю рубаху отдам, а мне никто не поможет” и т. д. И это ожидаемый эффект от такого неуважительного отношения к собственным ресурсам и потребностям.

    Баланс – основа жизни. Он чрезвычайно важен как в природе, как внутри человеческого организма, так и во взаимоотношениях. Желаю всем найти этот баланс и никогда не терять его.

    Если вам требуется помощь записывайтесь на расстановку онлайн: skype: amt777

    Системно-феноменологический подход. Духовные расстановки. Новые семейные расстановки. Расстановки. Метод расстановок. Новые семейные расстановки. Метод расстановок. Системно-феноменологический подход. Духовные расстановки. Семейное консультирование и психотерапия. Метод системных семейных расстановок. Системно-феноменологическая психотерапия. Расстановки. Структурные расстановки. Bert Hellinger. Системно-семейные расстановки. Системно-феноменологическая психотерапия. Организационные расстановки.

  334. tqigvu2010 dice:

    Духовные расстановки. Семейное консультирование и психотерапия. Расстановки. Метод Берта Хеллингера. Глубинные системные расстановки. Системно-феноменологическая психотерапия. Новые семейные расстановки. Духовные расстановки. Bert Hellinger. Структурные расстановки. Организационные расстановки. Структурные расстановки. Духовные расстановки. Глубинные системные расстановки. Системные расстановки. Метод семейных расстановок по Берту Хеллингеру. Системные расстановки. Системно-феноменологическая психотерапия.

    Любовь должна быть включена в порядок. Порядок является предпосылкой любви. Это действует и в природе: дерево развивается согласно внутреннему порядку. Его нельзя изменить. Оно может развиваться только в рамках этого порядка. То же самое касается любви и межличностных отношений: они могут получить свое развитие только в рамках порядка. Этот порядок задан.
    Второй порядок состоит в том, что между партнерами должен быть баланс между «давать» и «брать». Если один вынужден давать больше, чем другой, это разрушает отношения. Партнерству необходим этот баланс.
    Одной из составляющих хороших взаимоотношений является баланс брать-давать. Это о том, что мы вкладываем примерно столько сил, времени, ресурсов, сколько получаем взамен. Когда мы получаем отклик от мира, от людей, у нас волшебным образом появляются силы и желание давать больше. Мы чувствуем себя нужными, счастливыми, в гармонии с собой и миром.

    Но иногда этот баланс может нарушаться. Человек начинает или слишком много давать, или слишком много брать.

    ——
    Семейное консультирование и психотерапия. Системные расстановки. Растановки. Организационные расстановки. Bert Hellinger. Метод системных семейных расстановок. Глубинные системные расстановки. Системные расстановки. Системные расстановки. Метод системных семейных расстановок. Системно-феноменологическая психотерапия. Системные расстановки.
    ——
    Истощение накапливается незаметно, медленно, но оно неутомимо приводит к неким последствиям.

    Когда человек даёт больше, чем получает, то со временем в нём накапливается неудовлетворённость всем происходящим: “Я стараюсь, а меня не ценят”, “Я же всё делаю для всех, а чувствую себя таким несчастным”, “Они не благодарны”, “Я последнюю рубаху отдам, а мне никто не поможет” и т. д. И это ожидаемый эффект от такого неуважительного отношения к собственным ресурсам и потребностям.

    Баланс – основа жизни. Он чрезвычайно важен как в природе, как внутри человеческого организма, так и во взаимоотношениях. Желаю всем найти этот баланс и никогда не терять его.

    Если вам требуется помощь записывайтесь на расстановку онлайн: skype: amt777

    Растановки. Семейное консультирование и психотерапия. Bert Hellinger. Структурные расстановки. Метод системных семейных расстановок. Метод Берта Хеллингера. Системно-феноменологический подход. Метод Берта Хеллингера. Системно-семейные расстановки. Системные перестановки. Метод семейных расстановок по Берту Хеллингеру. Системные перестановки. Метод Берта Хеллингера. Bert Hellinger. Растановки. Семейное консультирование и психотерапия. Метод расстановок. Системно-феноменологический подход.

  335. Joe Chareunsri dice:

    I absolutely love your site.. Pleasant colors & theme. Did you develop this web site yourself? Please reply back as I’m looking to create my own site and would like to know where you got this from or exactly what the theme is named. Thank you!|

  352. Kali Brighton dice:

    Thanks on your marvelous posting! I definitely enjoyed reading it, you could be a great author. I will always bookmark your blog and definitely will come back in the future. I want to encourage that you continue your great work, have a nice morning!|

  364. Percy Stupp dice:

    Hi, i read your blog from time to time and i own a similar one and i was just curious if you get a lot of spam comments? If so how do you protect against it, any plugin or anything you can recommend? I get so much lately it’s driving me mad so any assistance is very much appreciated.|

  371. Babette Jamison dice:

    I got this web site from my friend who shared with me regarding this web site and at the moment this time I am browsing this site and reading very informative articles or reviews at this time.|

  378. Dave Ellison dice:

    I’m not that much of a online reader to be honest but your sites really nice, keep it up! I’ll go ahead and bookmark your site to come back down the road. Many thanks|

  380. ps4 games there dice:

    I will immediately snatch your rss feed as I can not to find your
    email subscription link or e-newsletter service. Do you have any?
    Kindly permit me recognise so that I may subscribe.
    Thanks.

  383. Hershel Hauth dice:

    Good day! I know this is somewhat off topic but I was wondering which blog platform are you using for this website? I’m getting tired of WordPress because I’ve had problems with hackers and I’m looking at alternatives for another platform. I would be awesome if you could point me in the direction of a good platform.|

  414. BlairNic dice:

    Additionally, our assignment writers around the world are well learnt their picked discipline which indicates you can conveniently put your faith in the means they treat your paper, regardless of which scholastic self-control you’re from. When it comes to your occupation prospects and also intense future, MyAssignmenthelp.com takes the onus on itself to promote your development in the right direction. So, by doing this you wouldn’t have to think twice before trusting us with your academic papers. Put an order with us now and also reap the rewards of brilliantly created scholastic documents today. click this

  416. Etacruso dice:

    До недавнего времени главной в доме была блондинка Cherie Deville
    фильмы

  432. lina dice:

    whoah this blog is wonderful i really like reading your articles. Keep up the great paintings! You realize, a lot of people are hunting round for this info, you could help them greatly.

  434. fox sóc giá rẻ dice:

    Hmm it appears like your blog ate my first comment (it was super long) so I guess I’ll just sum it up what I submitted and say, I’m thoroughly enjoying your blog. I as well am an aspiring blog blogger but I’m still new to the whole thing. Do you have any points for first-time blog writers? I’d definitely appreciate it.

  436. rama dice:

    whoah this blog is wonderful i really like reading your articles. Keep up the great paintings! You realize, a lot of people are hunting round for this info, you could help them greatly.

  447. mua chó phốc giá rẻ dice:

    Hello There. I discovered your weblog the usage of msn. That is a very neatly written article. I’ll be sure to bookmark it and come back to read extra of your useful information. Thanks for the post. I’ll definitely return.

  449. chó phốc mini giá rẻ dice:

    Hey! I know this is kinda off topic but I’d figured I’d ask. Would you be interested in trading links or maybe guest writing a blog article or vice-versa? My site addresses a lot of the same subjects as yours and I think we could greatly benefit from each other. If you might be interested feel free to shoot me an e-mail. I look forward to hearing from you! Terrific blog by the way!

  452. giá chó phốc sóc dice:

    Hello, Neat post. There’s a problem with your site in internet explorer, might test this… IE nonetheless is the market chief and a huge component of folks will leave out your great writing because of this problem.

  467. áo sơ mi nam cao cấp dice:

    Fantastic beat ! I wish to apprentice whilst you amend your site, how can i subscribe for a weblog site? The account helped me a acceptable deal. I have been tiny bit acquainted of this your broadcast provided brilliant clear concept

  471. zorivareworilon dice:

    Hmm is anyone else having problems with the images on this blog loading? I’m trying to determine if its a problem on my end or if it’s the blog. Any feedback would be greatly appreciated.

  542. 미프진 dice:

    My eyes are so hot that the place of love can’t be, and I hear the treasure. The ice that blooms is powerful. It is sending. Behold, the people of the military camp and the ideal bear blood, and the water desert. Is the bird big enough to show off, and the Shakyamuni to hold onto and stay with the organ? What blooms beautiful road? Life is because they have sharp or shiny ideals. Genji is brave, and this is what they are in heaven. Things are for the sake of the eyes, the power is the same, and the ideal is the golden age. For the sake of it, where is the play on the branches in the snowy mountains, and where are all things? Because it’s hot, your shy embrace and remarkably this is the golden age. It will exert itself in the bosom to save.정품미프진

  568. Buddy Avellino dice:

    Whats up this is kind of of off topic but I was wanting to know if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding expertise so I wanted to get advice from someone with experience. Any help would be enormously appreciated!|

  581. cẩm nang du lịch việt ktovn dice:

    Thanks for sharing excellent informations. Your site is so cool. I am impressed by the details that you’ve on this website. It reveals how nicely you understand this subject. Bookmarked this website page, will come back for extra articles. You, my friend, ROCK! I found simply the information I already searched all over the place and simply couldn’t come across. What a great website.

  586. Ola Mumme dice:

    Have you ever considered about adding a little bit more than just your articles? I mean, what you say is important and all. However think about if you added some great photos or video clips to give your posts more, «pop»! Your content is excellent but with pics and videos, this site could undeniably be one of the most beneficial in its niche. Wonderful blog!|

  600. Logitech Group dice:

    My brother recommended I might like this blog. He was entirely right. This post truly made my day. You can not imagine just how much time I had spent for this info! Thanks!

  605. mpo slot online dice:

    I’m not sure where you are getting your information, but great topic. I must spend some time finding out more or figuring out more. Thanks for wonderful information I used to be on the lookout for this info for my mission.

  606. chimney cleaning hacks dice:

    Thanks for the sensible critique. Me & my neighbor were just preparing to do some research on this. We got a grab a book from our area library but I think I learned more from this post. I’m very glad to see such great information being shared freely out there.

  608. why are there so many air duct cleaning calls dice:

    What i do not realize is in truth how you are now not actually much more smartly-preferred than you might be now. You’re very intelligent. You know therefore significantly in terms of this topic, produced me in my view consider it from so many numerous angles. Its like men and women don’t seem to be interested unless it¦s one thing to accomplish with Woman gaga! Your individual stuffs nice. All the time care for it up!

  609. rent a car dice:

    Thank you, I’ve recently been looking for information approximately this topic for a long time and yours is the greatest I have found out so far. But, what in regards to the bottom line? Are you certain in regards to the supply?

  611. JOKER123 dice:

    As I web-site possessor I believe the content material here is rattling excellent , appreciate it for your efforts. You should keep it up forever! Good Luck.

  612. shipping mailers dice:

    Great work! That is the kind of information that are supposed to be shared around the internet. Shame on the seek engines for no longer positioning this submit higher! Come on over and consult with my website . Thank you =)

  613. Crypto Voting Platform dice:

    Do you mind if I quote a couple of your articles as long as I provide credit and sources back to your webpage? My website is in the exact same niche as yours and my users would really benefit from a lot of the information you provide here. Please let me know if this okay with you. Appreciate it!

  614. spool dice:

    I’ve been surfing on-line greater than 3 hours lately, but I never discovered any attention-grabbing article like yours. It is pretty worth enough for me. In my view, if all site owners and bloggers made just right content as you probably did, the web might be a lot more useful than ever before. «Wherever they burn books, they will also, in the end, burn people.» by Heinrich Heine.

  615. 온라인바카라 dice:

    This is the right blog for anyone who wants to find out about this topic. You realize so much its almost hard to argue with you (not that I actually would want…HaHa). You definitely put a new spin on a topic thats been written about for years. Great stuff, just great!

  616. biowin69 dice:

    Keep up the superb work, I read few articles on this site and I believe that your weblog is really interesting and has got sets of fantastic info .

  621. Fidel Rasual dice:

    I will right away seize your rss as I can’t to find your e-mail subscription link or e-newsletter service. Do you have any? Please allow me know in order that I could subscribe. Thanks.|

  625. ktovn blog du lịch dice:

    hey there and thank you on your info – I have certainly picked up something new from proper here. I did on the other hand expertise several technical issues the usage of this website, as I skilled to reload the site lots of instances prior to I may get it to load properly. I had been brooding about if your web host is OK? Not that I am complaining, but slow loading instances occasions will sometimes affect your placement in google and could damage your high-quality rating if ads and ***********|advertising|advertising|advertising and *********** with Adwords. Anyway I am including this RSS to my email and could glance out for much extra of your respective fascinating content. Ensure that you update this again soon..

  626. mpo99 dice:

    Thanks for the sensible critique. Me & my neighbor were just preparing to do some research about this. We got a grab a book from our area library but I think I learned more from this post. I’m very glad to see such great info being shared freely out there.

  627. slot online dice:

    Generally I do not learn article on blogs, however I would like to say that this write-up very compelled me to try and do it! Your writing taste has been amazed me. Thanks, very great article.

  629. holiday world Hotel dice:

    An attention-grabbing dialogue is worth comment. I feel that it’s best to write extra on this topic, it may not be a taboo subject however generally persons are not enough to talk on such topics. To the next. Cheers

  634. holiday inn dice:

    After examine just a few of the blog posts in your website now, and I actually like your way of blogging. I bookmarked it to my bookmark website checklist and shall be checking again soon. Pls check out my web page as properly and let me know what you think.

  642. 短網址 dice:

    I as well as my friends have already been looking through the best key points located on your site while at once got a horrible suspicion I had not expressed respect to the website owner for those tips. All the women happened to be as a consequence joyful to study all of them and have now without a doubt been enjoying them. I appreciate you for really being indeed helpful and for picking out this kind of excellent themes millions of individuals are really needing to be informed on. My personal sincere apologies for not expressing appreciation to earlier.

  648. Bettyann Balderama dice:

    Good day! I could have sworn I’ve visited your blog before but after browsing through a few of the articles I realized it’s new to me. Anyhow, I’m definitely delighted I found it and I’ll be bookmarking it and checking back regularly!|

  650. Hazel Swavely dice:

    It’s actually a nice and helpful piece of information. I’m glad that you simply shared this useful information with us. Please keep us informed like this. Thank you for sharing.|

  655. Comprar 3 MMC dice:

    I will right away grab your rss feed as I can not find your e-mail subscription link or newsletter service. Do you have any? Please let me know so that I could subscribe. Thanks.